Course Modules

Module 1 Introduction to biological information

Lecture 1. Introduction to Genetics and Genomics.

Lecture 2. Introduction to DNA and DNA sequencing technologies

Module 2. Organisation of biological information: genes , messengers & proteins

Lecture 3. Concept of Gene, gene organisation and regulation

Lecture 4. How does the gene function ?

Module 3. Sequences and Sequence Formats

Lecture 5 . Sequence formats and encoding DNA, RNA and Protein sequences.

Lecture 6. Major databases for sequence information.

Exercise 1. Retrieve the genome sequence of a virus.

Module 4. Genes and Proteins

Lecture 7. Genes. What are they , how are they read and how to find them

Exercise 2. Gene identification for a given DNA sequence

Lecture 8. Concept of transcription and translation of sequences using examples.

Exercise 3. Finding the protein sequence from the gene

Module 5. Understanding proteins better

Lecture 9. Proteins . It is just not the sequence.

Lecture 10. Protein Secondary and Tertiary Structure

Exercise 4. Protein Databases and Resources

Module 6. Alignments and trees

Lecture 11 Pairwise Sequence Alignments

Lecture 12 Multiple Sequence Alignments and Phylogenetic trees

Module 7. Variants

Lecture 13 Concepts of variants.

Lecture 14 BLAST and Exercise

Module 8 Proteins and Models

Lecture 15 Models and Proteins

Exercise 6. Construct and evaluate the quality of a 3D model using web based resources. Use small molecules to dock against the given protein and interpret the docking scores.

Module 9 Short Project

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